Here are my top fives:
heroes:
1- leon kennedy
2- chris redfield
3- jill vallentine
4- sheva alomar
5- claire redfield
villians:
1- albert wesker(RE5)
2- ausmin sadler
3- jack krauser
4- nemesis(final form)
5- ricardo irving
enemies(strongest-weakest):
1- gatling gun majini
2- licker
3- executioner(red)
4- giant chainsaw man(RE4)
5- el-giganto
bosses:
1- uroburos 2nd form
2- U-8
3- "it"(RE4)
4- jill vallentine(RE5)
5- alexia(veronica)
weapons:
1- gatling gun(RE5)
2- grenade launcher(RE5)
3- assualt rifle(RE3)
4- "hand cannon"(RE4)
5- rocket luancher(RE5)