Okay, so in RE1 there is a puzzle called, "End of life" in which you have to press the buttons below the pictures in a specific order, otherwise the crows attack you. Now, has anyone ever thought that the portraits on the walls are of Spence?
I mean, Spencer as a newborn infact, a lively boy, young man, etc, etc, and a bold-looking old man?
Obviously this puzzle was changed in the REmake, to some bit with colored glass windowns, green, purple, yellow or whatever. But the original had a puzzle that might've been more significant.
Although the "bold-looking old man" looks a bit more like Father Time than Spencer, but of course this was before UC and RE5, sooo...